Darling Wa Namamono Ni Tsuki.
Setsuko, a daughter of a transsexual man who runs a cross-dressing bar.
She meets, falls in love with and then marries the handsome Dr. Tanabe.
Tanabe is normal, quiet and good at everything, while Setsuko is wholly different.
The series is about the couple struggling first to have, as well as maintain their sex and love life.